ARHGAP4 Antibody – Rabbit Polyclonal

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ARHGAP4: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; Golgi apparatus; growth cone; microtubule

Molecular Function: GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rac GTPase binding; Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity

Biological Process: cytoskeleton organization and biogenesis; negative regulation of axon extension; negative regulation of cell migration; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction