ATF2 Antibody – Rabbit Polyclonal

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.

Protein type: C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: cytoplasm; mitochondrial outer membrane; nucleoplasm; nucleus

Molecular Function: cAMP response element binding protein binding; chromatin binding; histone acetyltransferase activity; metal ion binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity

Biological Process: fat cell differentiation; histone acetylation; intra-S DNA damage checkpoint; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor-beta2 production; regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to osmotic stress; response to water deprivation; transcription from RNA polymerase II promoter