B3GALT6 Antibody – Rabbit Polyclonal

The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]

B3GALT6: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Belongs to the glycosyltransferase 31 family.

Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.4.1.134

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: Golgi medial cisterna; Golgi membrane; integral to membrane; membrane

Molecular Function: galactosylxylosylprotein 3-beta-galactosyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; UDP-galactosyltransferase activity

Biological Process: chondroitin sulfate biosynthetic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; protein amino acid glycosylation

Disease: Ehlers-danlos Syndrome, Progeroid Type, 2; Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 1, With Or Without Fractures