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BCO2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS767084

MBS767084 is an antibody targeting BCO2. Also known as BCO2 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BCO2, Polyclonal Antibody
Full Product Name
BCO2 Rabbit Polyclonal
Product Gene Name
anti-BCO2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
53,630 Da
OMIM
611740
Immunogen
Beta-carotene oxygenase 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-BCO2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-BCO2 antibody

Immunohistochemistry of paraffin-embedded human liver cancer using MBS767084 (BCO2 antibody) at dilution of 1:50
Rabbit Anti-BCO2 Polyclonal Antibody – Cat# MBS767084

Western Blot (WB) of anti-BCO2 antibody

L02 cells were subjected to SDS PAGE followed by western blot with MBS767084 (BCO2 antibody) at dilution of 1:800
Rabbit Anti-BCO2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS767084

Other Notes

Small volumes of anti-BCO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BCO2. It may not necessarily be applicable to this product.

NCBI GI #
374081847
NCBI GeneID
83875
NCBI Accession #
NP_001243326.1
UniProt Secondary Accession #
Q8IUS0; Q96JC8; Q96JY5; B0YIX5; B4DNC3; E9PBI8; E9PJJ1
UniProt Related Accession #
Q9BYV7
GenBank Nucleotide #
NM_001256397.1
NCBI Official Full Name
beta,beta-carotene 9',10'-oxygenase isoform c
NCBI Official Synonym Full Names
beta-carotene oxygenase 2
NCBI Official Symbol
BCO2
NCBI Official Synonym Symbols
BCDO2; B-DIOX-II
UniProt Protein Name
Beta,beta-carotene 9',10'-oxygenase
UniProt Synonym Protein Names
B-diox-II; Beta-carotene dioxygenase 2
Protein Family
Beta,beta-carotene 9',10'-oxygenase
UniProt Gene Name
BCO2
UniProt Synonym Gene Names
BCDO2
UniProt Entry Name
BCDO2_HUMAN
NCBI Protein Information
beta,beta-carotene 9',10'-oxygenase

NCBI Summary for BCO2

This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for BCO2

BCDO2: Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.13.11.71; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: intracellular; mitochondrial matrix; mitochondrion

Molecular Function: metal ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Biological Process: carotene catabolic process; carotene metabolic process; carotenoid metabolic process; regulation of mitochondrial membrane potential; retinal metabolic process; retinoic acid metabolic process; retinoid metabolic process; xanthophyll metabolic process
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Research Articles on BCO2

1. Role of beta-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BCO2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram

Diseases associated with anti-BCO2 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >5 publications with BCO2 and Fatty Liver
 Liver Diseases Antibodies  >4 publications with BCO2 and Liver Diseases
 Inflammation Antibodies  >2 publications with BCO2 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with BCO2 and Cardiovascular Diseases
 Carcinoma Antibodies  >1 publications with BCO2 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with BCO2 and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >1 publications with BCO2 and Liver Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with BCO2 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with BCO2 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with BCO2 and Liver Neoplasms

Organs/Tissues associated with anti-BCO2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with BCO2 and Liver
 Eye Antibodies  >6 publications with BCO2 and Eye
 Connective Tissue Antibodies  >6 publications with BCO2 and Connective Tissue
 Intestine Antibodies  >5 publications with BCO2 and Intestine
 Lung Antibodies  >2 publications with BCO2 and Lung
 Embryonic Tissue Antibodies  >2 publications with BCO2 and Embryonic Tissue
 Testis Antibodies  >2 publications with BCO2 and Testis
 Brain Antibodies  >2 publications with BCO2 and Brain
 Pancreas Antibodies  >2 publications with BCO2 and Pancreas
 Placenta Antibodies  >1 publications with BCO2 and Placenta
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