Biglycan (BGN) Antibody – Rabbit Polyclonal

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]

BGN: May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cell surface; cytoplasm; extracellular matrix; extracellular region; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix; sarcolemma; transport vesicle

Molecular Function: extracellular matrix binding; extracellular matrix structural constituent; glycosaminoglycan binding; protein kinase inhibitor activity

Biological Process: blood vessel remodeling; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; cytokine and chemokine mediated signaling pathway; dermatan sulfate biosynthetic process; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan