BMP10 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]

BMP10: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; Z disc

Molecular Function: cytokine activity; growth factor activity; hormone activity; protein binding; receptor serine/threonine kinase binding; telethonin binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; adult heart development; atrial cardiac muscle morphogenesis; BMP signaling pathway; cardiac muscle cell proliferation; cell adhesion; negative regulation of cell growth; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; sarcomere organization; ventricular cardiac muscle cell development; ventricular cardiac muscle morphogenesis