C5AR1 Antibody – Rabbit Polyclonal

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; cytoplasmic membrane-bound vesicle; cytosol; integral to plasma membrane; plasma membrane

Molecular Function: C5a anaphylatoxin receptor activity; complement component C5a binding; complement component C5a receptor activity

Biological Process: activation of MAPK activity; apoptosis; cell proliferation in hindbrain; cellular defense response; chemotaxis; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; immune response; inflammatory response; mRNA transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ regeneration; phospholipase C activation; positive regulation of angiogenesis; positive regulation of epithelial cell proliferation; regulation of complement activation; response to lipopolysaccharide; response to peptidoglycan; sensory perception of chemical stimulus; signal transduction