Calmodulin (CALM1) Antibody – Rabbit Polyclonal

This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 14q32.11

Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; growth cone; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle; voltage-gated potassium channel complex

Molecular Function: adenylate cyclase binding; calcium ion binding; calcium-dependent protein binding; inositol trisphosphate 3-kinase activity; ligand-gated ion channel activity; N-terminal myristoylation domain binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; Ras guanyl-nucleotide exchange factor activity; thioesterase binding; titin binding; type 3 metabotropic glutamate receptor binding

Biological Process: adenylate cyclase activation; detection of calcium ion; G-protein coupled receptor protein signaling pathway; G2/M transition of mitotic cell cycle; glycogen catabolic process; inositol phosphate metabolic process; MAPKKK cascade; muscle contraction; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of DNA binding; positive regulation of GTPase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to amphetamine; response to calcium ion; response to corticosterone stimulus; substantia nigra development; Wnt receptor signaling pathway, calcium modulating pathway

Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4