CaMKII alpha Antibody – Rabbit Polyclonal

CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family

Cellular Component: axon; cell junction; cell soma; cytoplasm; dendrite; dendrite cytoplasm; membrane; mitochondrion; nucleus; plasma membrane; postsynaptic density; synapse

Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; glutamate receptor binding; GTPase activating protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity

Biological Process: activation of NF-kappaB transcription factor; calcium ion transport; dendrite morphogenesis; G1/S transition of mitotic cell cycle; ionotropic glutamate receptor signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of calcium ion transport; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion