Cathepsin H (CTSH) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.16; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: cytosol; extracellular space; lysosome

Molecular Function: aminopeptidase activity; caspase activator activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; HLA-A specific activating MHC class I receptor activity; peptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: adaptive immune response; antigen processing and presentation; caspase activation; cellular protein metabolic process; immune response-regulating signal transduction; membrane protein proteolysis; metanephros development; negative regulation of apoptosis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; protein destabilization; proteolysis; proteolysis involved in cellular protein catabolic process; response to retinoic acid; surfactant homeostasis; T cell mediated cytotoxicity; zymogen activation