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CBLL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS767552

MBS767552 is an antibody targeting CBLL1. Also known as CBLL1 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CBLL1, Polyclonal Antibody
Full Product Name
CBLL1 Rabbit Polyclonal
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
54,390 Da
OMIM
606872
Immunogen
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CBLL1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-CBLL1 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS767552 (CBLL1 antibody) at dilution of 1:50
Rabbit Anti-CBLL1 Polyclonal Antibody – Cat# MBS767552

Western Blot (WB) of anti-CBLL1 antibody

DU 145 cells were subjected to SDS PAGE followed by western blot with MBS767552 (CBLL1 antibody) at dilution of 1:500
Rabbit Anti-CBLL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS767552

Other Notes

Small volumes of anti-CBLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CBLL1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CBLL1 protein
NCBI Official Synonym Full Names
Cbl proto-oncogene like 1
NCBI Official Symbol
CBLL1
NCBI Official Synonym Symbols
HAKAI; RNF188
UniProt Protein Name
E3 ubiquitin-protein ligase Hakai
UniProt Synonym Protein Names
Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; c-Cbl-like protein 1
UniProt Gene Name
CBLL1
UniProt Synonym Gene Names
HAKAI; RNF188
UniProt Entry Name
HAKAI_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase Hakai

NCBI Summary for CBLL1

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
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UniProt Comments for CBLL1

CBLL1: Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation.

Protein type: C2H2-type zinc finger protein; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; Motility/polarity/chemotaxis; EC 6.3.2.19; EC 6.3.2.-; Cell adhesion

Chromosomal Location of Human Ortholog: 7q22.3

Cellular Component: nuclear speck; ubiquitin ligase complex

Molecular Function: identical protein binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: cell-cell adhesion; negative regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; protein ubiquitination; regulation of cell adhesion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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