Rabbit Anti-CCKAR Polyclonal Antibody – Cat# MBS767609

Immunohistochemistry of paraffin-embedded human stomach tissue slide using MBS767609 (CCKAR-specific Antibody) at dilution of 1:50

CCKAR Antibody – Rabbit Polyclonal

Name: CCKAR Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS767609
Price: 330 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS767609

MBS767609 is an antibody targeting CCKAR. Also known as CCKAR-specific Rabbit Polyclonal. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CCKAR, Polyclonal Antibody

Full Product Name

CCKAR-specific Rabbit Polyclonal

Product Gene Name

anti-CCKAR antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Preparation and Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Molecular Weight

47,841 Da

OMIM

118444

Immunogen

Cholecystokinin A receptor

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CCKAR antibody

ELISA (EIA), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-CCKAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCKAR. It may not necessarily be applicable to this product.

NCBI GI #

4502607

NCBI GeneID

886

NCBI Accession #

NP_000721.1

UniProt Secondary Accession #

B2R9Z5

UniProt Related Accession #

P32238

GenBank Nucleotide #

NM_000730.2

NCBI Official Full Name

cholecystokinin receptor type A

NCBI Official Synonym Full Names

cholecystokinin A receptor

NCBI Official Symbol

CCKAR

NCBI Official Synonym Symbols

CCK-A; CCK1R; CCKRA; CCK1-R

UniProt Protein Name

Cholecystokinin receptor type A

UniProt Synonym Protein Names

Cholecystokinin-1 receptor; CCK1-R

Protein Family

Cholecystokinin receptor

UniProt Gene Name

CCKAR

UniProt Synonym Gene Names

CCKRA; CCK-A receptor; CCK-AR; CCK1-R

UniProt Entry Name

CCKAR_HUMAN

NCBI Protein Information

cholecystokinin receptor type A

NCBI Summary for CCKAR

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

UniProt Comments for CCKAR

CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: cytosol; endoplasmic reticulum; endosome; integral to plasma membrane; lysosome; plasma membrane; terminal button

Molecular Function: cholecystokinin receptor activity

Biological Process: actin cytoskeleton reorganization; axonogenesis; cellular response to hormone stimulus; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; forebrain development; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); gastric acid secretion; insulin secretion; neuron migration; organ regeneration; pancreas development; pancreatic juice secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of hormone secretion; regulation of potassium ion transport; response to glucocorticoid stimulus; response to heat; response to lipopolysaccharide; response to nutrient; response to radiation; response to starvation; thermoregulation

Research Articles on CCKAR

1. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CCKAR antibody

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Insulin Secretion Pathway antibodies	Insulin Secretion Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-CCKAR antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>11 publications with CCKAR and Obesity
Diabetes Mellitus Antibodies	>6 publications with CCKAR and Diabetes Mellitus
Disease Models, Animal Antibodies	>4 publications with CCKAR and Disease Models, Animal
Weight Gain Antibodies	>4 publications with CCKAR and Weight Gain
Kidney Diseases Antibodies	>3 publications with CCKAR and Kidney Diseases
Hyperglycemia Antibodies	>3 publications with CCKAR and Hyperglycemia
Neurobehavioral Manifestations Antibodies	>3 publications with CCKAR and Neurobehavioral Manifestations
Gallbladder Neoplasms Antibodies	>3 publications with CCKAR and Gallbladder Neoplasms
Weight Loss Antibodies	>2 publications with CCKAR and Weight Loss
Inflammation Antibodies	>2 publications with CCKAR and Inflammation

Organs/Tissues associated with anti-CCKAR antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>17 publications with CCKAR and Brain