CDC42EP2 Antibody – Rabbit Polyclonal

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; endomembrane system; membrane; microtubule cytoskeleton; plasma membrane

Molecular Function: GTP-Rho binding; GTPase activator activity; opioid peptide activity; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; positive regulation of actin filament polymerization; positive regulation of GTPase activity; positive regulation of protein complex assembly; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction