CDCA8 Antibody – Rabbit Polyclonal

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: chromocenter; chromosome, pericentric region; cytosol; intercellular bridge; midbody; nucleolus; nucleoplasm; nucleus; protein complex; spindle midzone

Molecular Function: protein binding

Biological Process: cell division; chromosome organization and biogenesis; mitotic metaphase plate congression; protein sumoylation; sister chromatid cohesion