CEBPA Antibody – Rabbit Polyclonal

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

C/EBP-alpha: a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: nucleolus; nucleus

Molecular Function: DNA binding; kinase binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: brown fat cell differentiation; cell maturation; cholesterol metabolic process; cytokine and chemokine mediated signaling pathway; embryonic placenta development; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; inner ear development; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization and biogenesis; myeloid cell differentiation; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urea cycle; viral reproduction; white fat cell differentiation

Disease: Leukemia, Acute Myeloid