CEBPB Antibody – Rabbit Polyclonal

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

C/EBP-beta: a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: acute-phase response; defense response to bacterium; immune response; inflammatory response; negative regulation of T cell proliferation; ovarian follicle development; positive regulation of fat cell differentiation; positive regulation of interleukin-4 production; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter