Rabbit Anti-CES3 Monoclonal Antibody – Cat# MBS8104906

CES3 Antibody – Rabbit Monoclonal

Name: CES3 Antibody; Monoclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8104906
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8104906

Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester +… More details

$370 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CES3, Monoclonal Antibody

Full Product Name

Recombinant Anti-CES3 Antibody, Rabbit Monoclonal

Product Gene Name

anti-CES3 antibody

Product Synonym Names

CES3/Carboxylesterase 3 Antibody, Rabbit MAb; carboxylesterase 3; Anti-ES31 Antibody; Anti-FLJ21736 Antibody; Anti-UNQ869/PRO1887 Antibody

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone Number

033

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; 0.2um filtered solution in PBS

Purity/Purification

Protein A

Specificity

Human CES3/Carboxylesterase 3

Preparation and Storage

This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

OMIM

605279

3D Structure

ModBase 3D Structure for Q6UWW8

Antibody Type

Recombinant Antibody

Immunogen

Recombinant Human CES3/Carboxylesterase 3 Protein

Conjugation

Unconjugated

Preparation

This antibody was obtained from a rabbit immunized with purified, recombinant Human CES3/Carboxylesterase 3 (rh CES3/Carboxylesterase 3).

Product Categories/Family for anti-CES3 antibody

Serine Proteases and Regulators

Applications Tested/Suitable for anti-CES3 antibody

Immunohistochemistry-Paraffin (IHC-P)

Application Notes for anti-CES3 antibody

IHC-P: 1:500-1:2000

Product References and Citations for anti-CES3 antibody

Augusteyn RC. et al., 1969, Biochim Biophys Acta. 171 (1): 128-37. Saito S. et al., 2003, J. Hum. Genet. 48: 249-70. Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91. Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11. Chen R. et al., 2009, J Proteome Res. 8: 651-61.

Other Notes

Small volumes of anti-CES3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CES3 purchase

MBS8104906 is an antibody targeting CES3. Also known as Recombinant Anti-CES3 Antibody, Rabbit Monoclonal. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CES3. It may not necessarily be applicable to this product.

NCBI GI #

33563374

NCBI GeneID

23491

NCBI Accession #

NP_079198.2

UniProt Primary Accession #

Q6UWW8

UniProt Related Accession #

Q6UWW8

GenBank Nucleotide #

NM_024922.6

NCBI Official Full Name

carboxylesterase 3 isoform 1

NCBI Official Synonym Full Names

carboxylesterase 3

NCBI Official Symbol

CES3

NCBI Official Synonym Symbols

ES31

UniProt Protein Name

Carboxylesterase 3

UniProt Synonym Protein Names

Liver carboxylesterase 31 homolog

Protein Family

Carboxylesterase

UniProt Gene Name

CES3

UniProt Entry Name

EST3_HUMAN

NCBI Protein Information

carboxylesterase 3

NCBI Summary for CES3

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

UniProt Comments for CES3

Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Catalytic activity: A carboxylic ester + H2O = an alcohol + a carboxylate.

Subcellular location: Endoplasmic reticulum lumen

By similarity.

Tissue specificity: Expressed in liver, colon and small intestine. Ref.1 Ref.8 Ref.9

Post-translational modification: N-glycosylated. Ref.1

Sequence similarities: Belongs to the type-B carboxylesterase/lipase family.

Biophysicochemical propertiesKinetic parameters:KM=137 µM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin Ref.1KM=460 µM for 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin

Research Articles on CES3

1. This study provides the first evidence of functional compensation whereby increased expression of CES3 restores intracellular cholesteryl ester hydrolytic activity and free cholesterol efflux in CES1-deficient cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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