CFTR Antibody – Rabbit Polyclonal

CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Channel, chloride; EC 3.6.3.49; Hydrolase

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle membrane; cytosol; early endosome; early endosome membrane; microvillus; plasma membrane; protein complex; recycling endosome

Molecular Function: ATP binding; bicarbonate transmembrane transporter activity; channel-conductance-controlling ATPase activity; chloride channel activity; chloride channel inhibitor activity; chloride transmembrane transporter activity; enzyme binding; PDZ domain binding

Biological Process: bicarbonate transport; body fluid secretion; cellular response to hormone stimulus; chloride transport; cholesterol biosynthetic process; cholesterol transport; intracellular pH elevation; iodide transport; lung development; membrane hyperpolarization; positive regulation of exocytosis; positive regulation of vasodilation; response to cytokine stimulus; response to drug; response to estrogen stimulus; response to peptide hormone stimulus; sperm capacitation; transepithelial chloride transport; vasodilation; vesicle docking during exocytosis; water transport