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CHCHD4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS767869

MBS767869 is an antibody targeting CHCHD4. Also known as CHCHD4 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CHCHD4, Polyclonal Antibody
Full Product Name
CHCHD4 Rabbit Polyclonal
Product Gene Name
anti-CHCHD4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
17,385 Da
OMIM
611077
Immunogen
Coiled-coil-helix-coiled-coil-helix domain containing 4
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CHCHD4 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-CHCHD4 antibody

Immunohistochemistry of paraffin-embedded human kidney using MBS767869 (CHCHD4 antibody) at dilution of 1:100
Rabbit Anti-CHCHD4 Polyclonal Antibody – Cat# MBS767869

Testing Data of anti-CHCHD4 antibody

Rabbit Anti-CHCHD4 Polyclonal Antibody, Testing Data – Cat# MBS767869

Western Blot (WB) of anti-CHCHD4 antibody

rat brain tissue were subjected to SDS PAGE followed by western blot with MBS767869 (CHCHD4 Antibody) at dilution of 1:1500
Rabbit Anti-CHCHD4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS767869

Other Notes

Small volumes of anti-CHCHD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHCHD4. It may not necessarily be applicable to this product.

NCBI GI #
31417005
NCBI GeneID
131474
NCBI Accession #
AAH17082.2
UniProt Secondary Accession #
Q96AI2; Q96MY6; A8K3Z9
UniProt Related Accession #
Q8N4Q1
NCBI Official Full Name
CHCHD4 protein
NCBI Official Synonym Full Names
coiled-coil-helix-coiled-coil-helix domain containing 4
NCBI Official Symbol
CHCHD4
NCBI Official Synonym Symbols
MIA40; TIMM40
UniProt Protein Name
Mitochondrial intermembrane space import and assembly protein 40
UniProt Synonym Protein Names
Coiled-coil-helix-coiled-coil-helix domain-containing protein 4
Protein Family
Mitochondrial intermembrane space import and assembly protein
UniProt Gene Name
CHCHD4
UniProt Synonym Gene Names
MIA40
UniProt Entry Name
MIA40_HUMAN
NCBI Protein Information
mitochondrial intermembrane space import and assembly protein 40

NCBI Summary for CHCHD4

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]

UniProt Comments for CHCHD4

CHCHD4: Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (Probable). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: mitochondrial intermembrane space; mitochondrion

Molecular Function: protein disulfide oxidoreductase activity

Biological Process: 'de novo' posttranslational protein folding; protein import into mitochondrial intermembrane space; protein maturation via protein folding
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Research Articles on CHCHD4

1. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CHCHD4 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram

Organs/Tissues associated with anti-CHCHD4 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with CHCHD4 and Skin
 Brain Antibodies  >1 publications with CHCHD4 and Brain
 Lung Antibodies  >1 publications with CHCHD4 and Lung
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