CHIT1 Antibody – Rabbit Polyclonal

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

CHIT1: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Secreted, signal peptide; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Secreted; EC 3.2.1.14

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; extracellular space; lysosome

Molecular Function: chitin binding; chitinase activity; endochitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds

Biological Process: carbohydrate metabolic process; chitin catabolic process; immune response; polysaccharide catabolic process; response to bacterium

Disease: Chitotriosidase Deficiency