CHST11 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CHST11: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. Belongs to the sulfotransferase 2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Energy Metabolism - sulfur; Membrane protein, integral; Transferase; EC 2.8.2.5

Chromosomal Location of Human Ortholog: 12q

Cellular Component: Golgi membrane; integral to membrane; membrane

Molecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activity; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Biological Process: carbohydrate biosynthetic process; chondrocyte development; chondroitin sulfate biosynthetic process; developmental growth; embryonic digit morphogenesis; embryonic viscerocranium morphogenesis; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; polysaccharide localization; post-embryonic development; regulation of cell proliferation; respiratory gaseous exchange