CIB1 Antibody – Rabbit Polyclonal

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CIB1: May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q25.3-q26

Cellular Component: apical plasma membrane; axon; cell soma; centrosome; cytoplasm; dendrite; endoplasmic reticulum; filopodium tip; Golgi apparatus; growth cone; lamellipodium; membrane; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; sarcolemma; vesicle

Molecular Function: calcium ion binding; calcium-dependent protein kinase inhibitor activity; protein anchor; protein binding; protein C-terminus binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; Ras GTPase binding

Biological Process: activation of NF-kappaB transcription factor; angiogenesis; apoptosis; cell adhesion; cell division; cytoplasmic microtubule organization and biogenesis; double-strand break repair; endomitotic cell cycle; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of megakaryocyte differentiation; negative regulation of microtubule depolymerization; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; platelet formation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of protein amino acid phosphorylation; regulation of cell division; regulation of cell proliferation; response to DNA damage stimulus; spermatid development