Claudin 7 (CLDN7) Antibody – Rabbit Polyclonal

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; integral to membrane; lateral plasma membrane; tight junction

Molecular Function: cell adhesion molecule binding; identical protein binding; protein binding; structural molecule activity

Biological Process: calcium-independent cell-cell adhesion; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of protein homooligomerization; positive regulation of cell proliferation; positive regulation of defense response to virus by host