CLCA2 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]

CLCA5: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.

Protein type: Membrane protein, integral; Channel, chloride

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: basal plasma membrane; cell junction; extracellular region; integral to plasma membrane; nucleus; plasma membrane

Molecular Function: chloride channel activity; intracellular calcium activated chloride channel activity; ligand-gated ion channel activity; metal ion binding; metalloendopeptidase activity

Biological Process: cell adhesion; proteolysis; transport