CLSTN1 Antibody – Rabbit Polyclonal

CLSTN1: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: cell junction; cell projection; cell surface; endoplasmic reticulum; extracellular region; Golgi apparatus; integral to membrane; membrane; nucleus; plasma membrane; postsynaptic membrane; synapse

Molecular Function: beta-amyloid binding; calcium ion binding; kinesin binding; protein binding; X11-like protein binding

Biological Process: cell adhesion; cellular calcium ion homeostasis; homophilic cell adhesion; positive regulation of synaptic transmission; positive regulation of synaptogenesis; regulation of cell growth; synaptic transmission