CLTA Antibody – Rabbit Polyclonal

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

CLTA: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Belongs to the clathrin light chain family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin vesicle coat; cytoplasmic membrane-bound vesicle; cytosol; intracellular membrane-bound organelle; membrane; plasma membrane; trans-Golgi network membrane

Molecular Function: clathrin heavy chain binding; peptide binding; protein binding; structural molecule activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; intracellular protein transport; microtubule-based movement; negative regulation of epidermal growth factor receptor signaling pathway