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COLEC11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9125977
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This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COLEC11, Polyclonal Antibody
Full Product Name
COLEC11 Polyclonal Antibody
Product Gene Name
anti-COLEC11 antibody
Product Synonym Names
3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Zebrafish
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
271
OMIM
phenotype 612502
3D Structure
ModBase 3D Structure for Q9BWP8
Species
Human
Immunogen
Recombinant protein of human COLEC11
Calculated Molecular Weight
29kDa

Product Categories/Family for anti-COLEC11 antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-COLEC11 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-COLEC11 antibody
WB: 1:200-1:2000
IF: 1:50-1:200

Western Blot (WB) of anti-COLEC11 antibody

Western blot analysis of extracts of various cell lines, using COLEC11 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 60s.
Rabbit Anti-COLEC11 Polyclonal Antibody – Cat# MBS9125977

Immunohistochemistry (IHC) of anti-COLEC11 antibody

Immunohistochemistry of paraffin-embedded rat brain using COLEC11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-COLEC11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9125977

Immunohistochemistry (IHC) of anti-COLEC11 antibody

Immunohistochemistry of paraffin-embedded human prostate using COLEC11 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-COLEC11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9125977

Other Notes

Small volumes of anti-COLEC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COLEC11 purchase

MBS9125977 is an antibody targeting COLEC11. Also known as COLEC11 Polyclonal Antibody. Reactive in Human, Mouse, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COLEC11. It may not necessarily be applicable to this product.

NCBI GI #
74733453
NCBI GeneID
78989
NCBI Accession #
Q9BWP8.1
UniProt Primary Accession #
Q9BWP8
UniProt Secondary Accession #
Q5CZ85; A1IGE4; A1IGE5; A1IGE6; A7VJJ2; A7VJJ3; A7VJJ4; A7VJJ5; B2R9M5; B4E1G0; J3KQY9
UniProt Related Accession #
Q9BWP8
NCBI Official Full Name
Collectin-11
NCBI Official Synonym Full Names
collectin sub-family member 11
NCBI Official Symbol
COLEC11
NCBI Official Synonym Symbols
3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb
UniProt Protein Name
Collectin-11
UniProt Synonym Protein Names
Collectin kidney protein 1; CL-K1
Protein Family
Collectin
UniProt Gene Name
COLEC11
UniProt Synonym Gene Names
CL-K1
UniProt Entry Name
COL11_HUMAN
NCBI Protein Information
collectin-11; Collectin K1; collectin kidney protein 1

UniProt Comments for COLEC11

COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: collagen; extracellular region

Molecular Function: mannose binding

Biological Process: receptor-mediated endocytosis; multicellular organismal development; developmental process

Disease: 3mc Syndrome 2
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Research Articles on COLEC11

1. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2, the complex deposited C4b.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-COLEC11 antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram

Diseases associated with anti-COLEC11 antibody

 Disease Name  Pubmed Publications
 Learning Disorders Antibodies  >1 publications with COLEC11 and Learning Disorders
 Disease Models, Animal Antibodies  >1 publications with COLEC11 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with COLEC11 and Inflammation
 Liver Diseases Antibodies  >1 publications with COLEC11 and Liver Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with COLEC11 and Craniofacial Abnormalities

Organs/Tissues associated with anti-COLEC11 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with COLEC11 and Kidney
 Liver Antibodies  >2 publications with COLEC11 and Liver
 Heart Antibodies  >1 publications with COLEC11 and Heart
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