CREBL2 Antibody – Rabbit Polyclonal

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

CREBL2: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. Belongs to the bZIP family. ATF subfamily.

Protein type: Transcription factor; Tumor suppressor

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: cell cycle; cell differentiation; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription, DNA-dependent; protein stabilization; signal transduction; transcription, DNA-dependent