CRHR2 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: dendrite; Golgi apparatus; integral to plasma membrane; nerve terminal; perikaryon; plasma membrane; rough endoplasmic reticulum

Molecular Function: corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; peptide hormone binding; protein binding

Biological Process: actin filament organization; activation of NF-kappaB transcription factor; catecholamine biosynthetic process; cell surface receptor linked signal transduction; cerebellum development; epithelial cell differentiation; G-protein signaling, coupled to cAMP nucleotide second messenger; hormone-mediated signaling; hypothalamus development; negative regulation of cAMP biosynthetic process; negative regulation of epinephrine secretion; negative regulation of follicle-stimulating hormone secretion; negative regulation of luteinizing hormone secretion; positive regulation of blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of heart rate; positive regulation of interleukin-6 production; positive regulation of serotonin secretion; positive regulation of stress-activated MAPK cascade; protein kinase C activation; sensory perception of pain; skeletal muscle growth