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CRLS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768214

MBS768214 is an antibody targeting CRLS1. Also known as CRLS1 Rabbit Polyclonal. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CRLS1, Polyclonal Antibody
Full Product Name
CRLS1 Rabbit Polyclonal
Product Gene Name
anti-CRLS1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
22,584 Da
OMIM
608188
Immunogen
Cardiolipin synthase 1
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CRLS1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-CRLS1 antibody

Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS768214 (CRLS1 Antibody) at dilution of 1:200
Rabbit Anti-CRLS1 Polyclonal Antibody – Cat# MBS768214

Western Blot (WB) of anti-CRLS1 antibody

mouse heart tissue were subjected to SDS PAGE followed by western blot with MBS768214 (CRLS1 antibody) at dilution of 1:300
Rabbit Anti-CRLS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768214

Other Notes

Small volumes of anti-CRLS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRLS1. It may not necessarily be applicable to this product.

NCBI GI #
46362465
NCBI GeneID
54675
NCBI Accession #
AAH69010.1
UniProt Secondary Accession #
Q27RP0; Q69YQ5; D3DW09; E9PAT4
UniProt Related Accession #
Q9UJA2
NCBI Official Full Name
CRLS1 protein
NCBI Official Synonym Full Names
cardiolipin synthase 1
NCBI Official Symbol
CRLS1
NCBI Official Synonym Symbols
CLS; CLS1; GCD10; C20orf155; dJ967N21.6
UniProt Protein Name
Cardiolipin synthase (CMP-forming)
UniProt Synonym Protein Names
Protein GCD10 homolog
UniProt Gene Name
CRLS1
UniProt Synonym Gene Names
C20orf155; CLS1; CLS
UniProt Entry Name
CRLS1_HUMAN
NCBI Protein Information
cardiolipin synthase (CMP-forming)

NCBI Summary for CRLS1

This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]

UniProt Comments for CRLS1

CRLS1: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Lipid Metabolism - glycerophospholipid; EC 2.7.8.-; Mitochondrial; Transferase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20p13-p12.3

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity; cardiolipin synthase activity; CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

Biological Process: cardiolipin biosynthetic process
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Research Articles on CRLS1

1. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CRLS1 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Synthesis Of CL Pathway antibodies  Synthesis Of CL Pathway Diagram

Diseases associated with anti-CRLS1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with CRLS1 and Inflammation
 Lung Neoplasms Antibodies  >1 publications with CRLS1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >1 publications with CRLS1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with CRLS1 and Liver Neoplasms

Organs/Tissues associated with anti-CRLS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CRLS1 and Liver
 Adipose Tissue Antibodies  >1 publications with CRLS1 and Adipose Tissue
 Heart Antibodies  >1 publications with CRLS1 and Heart
 Vascular Antibodies  >1 publications with CRLS1 and Vascular
 Placenta Antibodies  >1 publications with CRLS1 and Placenta
 Connective Tissue Antibodies  >1 publications with CRLS1 and Connective Tissue
 Lung Antibodies  >1 publications with CRLS1 and Lung
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