CUX1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral; DNA-binding

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: cytosol; Golgi apparatus; Golgi membrane; integral to Golgi membrane; nucleoplasm; nucleus

Molecular Function: protein binding, bridging; protein-tyrosine kinase activity; sequence-specific DNA binding

Biological Process: intra-Golgi vesicle-mediated transport; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; peptidyl-tyrosine phosphorylation; positive regulation of dendrite morphogenesis; regulation of transcription from RNA polymerase II promoter; retrograde transport, vesicle recycling within Golgi; transcription, DNA-dependent