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CYP2J2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768393

MBS768393 is an antibody targeting CYP2J2. Also known as CYP2J2 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CYP2J2, Polyclonal Antibody
Full Product Name
CYP2J2 Rabbit Polyclonal
Product Gene Name
anti-CYP2J2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
57,611 Da
OMIM
601258
Immunogen
Cytochrome P450, family 2, subfamily J, polypeptide 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CYP2J2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-CYP2J2 antibody

Immunohistochemistry of paraffin-embedded human liver cancer using MBS768393 (CYP2J2 antibody) at dilution of 1:50
Rabbit Anti-CYP2J2 Polyclonal Antibody – Cat# MBS768393

Western Blot (WB) of anti-CYP2J2 antibody

mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS768393 (CYP2J2 antibody) at dilution of 1:500
Rabbit Anti-CYP2J2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768393

Other Notes

Small volumes of anti-CYP2J2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP2J2. It may not necessarily be applicable to this product.

NCBI GI #
18491008
NCBI GeneID
1573
NCBI Accession #
NP_000766.2
UniProt Secondary Accession #
Q8TF13; B2RD33
UniProt Related Accession #
P51589
GenBank Nucleotide #
NM_000775.3
NCBI Official Full Name
cytochrome P450 2J2
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily J member 2
NCBI Official Symbol
CYP2J2
NCBI Official Synonym Symbols
CPJ2; CYPIIJ2
UniProt Protein Name
Cytochrome P450 2J2
UniProt Synonym Protein Names
Arachidonic acid epoxygenase; CYPIIJ2
Protein Family
Cytochrome
UniProt Gene Name
CYP2J2
UniProt Entry Name
CP2J2_HUMAN
NCBI Protein Information
cytochrome P450 2J2

NCBI Summary for CYP2J2

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
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UniProt Comments for CYP2J2

CYP2J2: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.1; Oxidoreductase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Contractile

Chromosomal Location of Human Ortholog: 1p31.3-p31.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; arachidonic acid epoxygenase activity; heme binding; iron ion binding; monooxygenase activity; steroid hydroxylase activity

Biological Process: epoxygenase P450 pathway; icosanoid metabolic process; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process
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Research Articles on CYP2J2

1. Our results suggest that individuals with any conventional risk factor for MI along with CYP2J2*7 variant allele may be predisposed to risk of myocardial infarct in South Indian population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYP2J2 antibody

 Reference Product  PubMed Publications
 CYP3A4 antibody  >42 publications with CYP2J2 and CYP3A4
 CYP1A2 antibody  >23 publications with CYP2J2 and CYP1A2
 CYP4A11 antibody  >20 publications with CYP2J2 and CYP4A11
 CYP4F2 antibody  >13 publications with CYP2J2 and CYP4F2
 EPHX2 antibody  >13 publications with CYP2J2 and EPHX2
 CYP4F3 antibody  >3 publications with CYP2J2 and CYP4F3
 ALOX15 antibody  >2 publications with CYP2J2 and ALOX15

Pathways associated with anti-CYP2J2 antibody

 Products by Pathway  Pathway Diagram
 Arachidonate Epoxygenase / Epoxide Hydrolase Pathway antibodies  Arachidonate Epoxygenase / Epoxide Hydrolase Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Fatty Acids Pathway antibodies  Fatty Acids Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Linoleic Acid Metabolism Pathway antibodies  Linoleic Acid Metabolism Pathway Diagram

Diseases associated with anti-CYP2J2 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >116 publications with CYP2J2 and Cardiovascular Diseases
 Hypertension Antibodies  >78 publications with CYP2J2 and Hypertension
 Inflammation Antibodies  >59 publications with CYP2J2 and Inflammation
 Heart Diseases Antibodies  >48 publications with CYP2J2 and Heart Diseases
 Kidney Diseases Antibodies  >18 publications with CYP2J2 and Kidney Diseases
 Fatty Liver Antibodies  >14 publications with CYP2J2 and Fatty Liver
 Nervous System Diseases Antibodies  >14 publications with CYP2J2 and Nervous System Diseases
 Necrosis Antibodies  >13 publications with CYP2J2 and Necrosis
 Liver Diseases Antibodies  >12 publications with CYP2J2 and Liver Diseases
 Atherosclerosis Antibodies  >10 publications with CYP2J2 and Atherosclerosis

Organs/Tissues associated with anti-CYP2J2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >100 publications with CYP2J2 and Liver
 Kidney Antibodies  >98 publications with CYP2J2 and Kidney
 Heart Antibodies  >73 publications with CYP2J2 and Heart
 Muscle Antibodies  >60 publications with CYP2J2 and Muscle
 Brain Antibodies  >38 publications with CYP2J2 and Brain
 Intestine Antibodies  >29 publications with CYP2J2 and Intestine
 Lung Antibodies  >29 publications with CYP2J2 and Lung
 Placenta Antibodies  >7 publications with CYP2J2 and Placenta
 Bone Antibodies  >5 publications with CYP2J2 and Bone
 Skin Antibodies  >4 publications with CYP2J2 and Skin
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