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Cytohesin 2 (CYTH2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768423

MBS768423 is an antibody targeting CYTH2. Also known as Cytohesin 2 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Testing Data View PDF
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Product Overview

Product Name
Cytohesin 2 (CYTH2), Polyclonal Antibody
Full Product Name
Cytohesin 2 Rabbit Polyclonal
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
46,489 Da
OMIM
602488
Immunogen
Cytohesin 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CYTH2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-CYTH2 antibody

Immunohistochemistry of paraffin-embedded human ovary tumor using MBS768423 (CYTH2 antibody) at dilution of 1:50
Rabbit Anti-CYTH2 Polyclonal Antibody – Cat# MBS768423

Testing Data of anti-CYTH2 antibody

Rabbit Anti-CYTH2 Polyclonal Antibody, Testing Data – Cat# MBS768423

Western Blot (WB) of anti-CYTH2 antibody

mouse heart tissue were subjected to SDS PAGE followed by western blot with MBS768423 (CYTH2 antibody) at dilution of 1:1000
Rabbit Anti-CYTH2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768423

Other Notes

Small volumes of anti-CYTH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYTH2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Cytohesin 2
NCBI Official Synonym Full Names
cytohesin 2
NCBI Official Symbol
CYTH2
NCBI Official Synonym Symbols
ARNO; CTS18; PSCD2; SEC7L; PSCD2L; CTS18.1; Sec7p-L; Sec7p-like
UniProt Protein Name
Cytohesin-2
UniProt Synonym Protein Names
ARF exchange factor; ARF nucleotide-binding site opener; Protein ARNO; PH, SEC7 and coiled-coil domain-containing protein 2
Protein Family
UniProt Gene Name
CYTH2
UniProt Synonym Gene Names
ARNO; PSCD2; PSCD2L; Protein ARNO
UniProt Entry Name
CYH2_HUMAN
NCBI Protein Information
cytohesin-2

NCBI Summary for CYTH2

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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UniProt Comments for CYTH2

cytohesin 2: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytoplasm; cytosol; Golgi membrane; growth cone; membrane; plasma membrane

Molecular Function: ARF guanyl-nucleotide exchange factor activity; lipid binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; endocytosis; positive regulation of GTPase activity; regulation of ARF protein signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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