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Cytokeratin 18 (KRT18) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768437

MBS768437 is an antibody targeting KRT18. Also known as Cytokeratin 18 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Cytokeratin 18 (KRT18), Polyclonal Antibody
Full Product Name
Cytokeratin 18 Rabbit Polyclonal
Product Gene Name
anti-KRT18 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
48,058 Da
OMIM
148070
3D Structure
ModBase 3D Structure for P05783
Immunogen
Keratin 18
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-KRT18 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-KRT18 antibody

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using MBS768437 (KRT18 Antibody) at dilution of 1:200
Rabbit Anti-KRT18 Polyclonal Antibody – Cat# MBS768437

Immunofluorescence (IF) of anti-KRT18 antibody

Immunofluorescent analysis of (-20 degree C Ethanol) fixed HeLa cells using MBS768437 (KRT18 Antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG (H+L)
Rabbit Anti-KRT18 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS768437

Testing Data of anti-KRT18 antibody

Rabbit Anti-KRT18 Polyclonal Antibody, Testing Data – Cat# MBS768437

Western Blot (WB) of anti-KRT18 antibody

A431 cells were subjected to SDS PAGE followed by western blot with MBS768437 (KRT18 antibody) at dilution of 1:1000
Rabbit Anti-KRT18 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768437

Other Notes

Small volumes of anti-KRT18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT18. It may not necessarily be applicable to this product.

NCBI GI #
34037
NCBI GeneID
3875
NCBI Accession #
CAA31375.1
UniProt Primary Accession #
P05783
UniProt Secondary Accession #
Q53G38; Q5U0N8; Q9BW26
UniProt Related Accession #
P05783
NCBI Official Full Name
cytokeratin 18
NCBI Official Synonym Full Names
keratin 18
NCBI Official Symbol
KRT18
NCBI Official Synonym Symbols
K18; CK-18; CYK18
UniProt Protein Name
Keratin, type I cytoskeletal 18
UniProt Synonym Protein Names
Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
Protein Family
Keratin
UniProt Gene Name
KRT18
UniProt Synonym Gene Names
CYK18; CK-18; K18
UniProt Entry Name
K1C18_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 18

NCBI Summary for KRT18

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for KRT18

K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis.

Protein type: Nucleolus; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm

Molecular Function: protein binding; structural molecule activity

Biological Process: anatomical structure morphogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; viral reproduction

Disease: Cirrhosis, Familial
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Research Articles on KRT18

1. As an apoptosis-related biomarker, serum M30 [M30 cytokeratin-18 peptide, human ] level has a merit to be the most promising test for prediction or differential diagnosis of HELLP syndrome in PE patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT18 antibody

 Reference Product  PubMed Publications
 KRT8 antibody  >63 publications with KRT18 and KRT8
 EGR1 antibody  >1 publications with KRT18 and EGR1
 TCHP antibody  >1 publications with KRT18 and TCHP
 YWHAZ antibody  >1 publications with KRT18 and YWHAZ
 CASP6 antibody  >1 publications with KRT18 and CASP6

Pathways associated with anti-KRT18 antibody

 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram

Diseases associated with anti-KRT18 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >42 publications with KRT18 and Liver Diseases
 Carcinoma Antibodies  >36 publications with KRT18 and Carcinoma
 Fibrosis Antibodies  >18 publications with KRT18 and Fibrosis
 Breast Neoplasms Antibodies  >17 publications with KRT18 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >17 publications with KRT18 and Neoplasm Metastasis
 Fatty Liver Antibodies  >17 publications with KRT18 and Fatty Liver
 Adenocarcinoma Antibodies  >16 publications with KRT18 and Adenocarcinoma
 Inflammation Antibodies  >13 publications with KRT18 and Inflammation
 Disease Models, Animal Antibodies  >10 publications with KRT18 and Disease Models, Animal
 Necrosis Antibodies  >10 publications with KRT18 and Necrosis

Organs/Tissues associated with anti-KRT18 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >57 publications with KRT18 and Liver
 Blood Antibodies  >35 publications with KRT18 and Blood
 Prostate Antibodies  >10 publications with KRT18 and Prostate
 Bone Antibodies  >9 publications with KRT18 and Bone
 Lymph Antibodies  >8 publications with KRT18 and Lymph
 Lymph Node Antibodies  >8 publications with KRT18 and Lymph Node
 Muscle Antibodies  >7 publications with KRT18 and Muscle
 Kidney Antibodies  >7 publications with KRT18 and Kidney
 Stomach Antibodies  >7 publications with KRT18 and Stomach
 Eye Antibodies  >7 publications with KRT18 and Eye
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