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DBNL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768489

MBS768489 is an antibody targeting DBNL. Also known as DBNL Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DBNL, Polyclonal Antibody
Full Product Name
DBNL Rabbit Polyclonal
Product Gene Name
anti-DBNL antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
48,341 Da
Immunogen
Drebrin-like
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DBNL antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-DBNL antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS768489 (DBNL antibody) at dilution of 1:100
Rabbit Anti-DBNL Polyclonal Antibody – Cat# MBS768489

Testing Data of anti-DBNL antibody

Rabbit Anti-DBNL Polyclonal Antibody, Testing Data – Cat# MBS768489

Western Blot (WB) of anti-DBNL antibody

mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS768489 (DBNL antibody) at dilution of 1:1000
Rabbit Anti-DBNL Polyclonal Antibody, Western Blot (WB) – Cat# MBS768489

Other Notes

Small volumes of anti-DBNL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DBNL. It may not necessarily be applicable to this product.

NCBI GI #
226423873
NCBI GeneID
13169
NCBI Accession #
NP_001139781.1
UniProt Secondary Accession #
Q3TG34; Q3U5X3; Q3U8I5; Q3UZ33; Q5NCI5; Q5NCI6; Q5NCI7; Q80WP1; Q8BH56
UniProt Related Accession #
Q62418
GenBank Nucleotide #
NM_001146309.1
NCBI Official Full Name
drebrin-like protein isoform 3
NCBI Official Synonym Full Names
drebrin-like
NCBI Official Symbol
Dbnl
NCBI Official Synonym Symbols
Abp1; SH3P7; mAbp1
UniProt Protein Name
Drebrin-like protein
UniProt Synonym Protein Names
Actin-binding protein 1; SH3 domain-containing protein 7
Protein Family
Drebrin-like protein
UniProt Gene Name
Dbnl
UniProt Entry Name
DBNL_MOUSE
NCBI Protein Information
drebrin-like protein

UniProt Comments for DBNL

DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Cellular Component: cell cortex; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoskeleton; dendrite; endosome; Golgi apparatus; intracellular; lamellipodium; membrane; plasma membrane; podosome; postsynaptic density; ruffle; synapse

Molecular Function: actin binding; actin filament binding; protein binding; protein C-terminus binding; protein domain specific binding

Biological Process: actin filament bundle formation; actin filament severing; adaptive immune response; barbed-end actin filament capping; endocytosis; immune system process; neurite morphogenesis; Rac protein signal transduction; receptor-mediated endocytosis; synaptogenesis; transport
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Research Articles on DBNL

1. mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DBNL antibody

 Reference Product  PubMed Publications
 Syk antibody  >3 publications with DBNL and Syk

Pathways associated with anti-DBNL antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-DBNL antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with DBNL and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with DBNL and Carcinoma
 Fibrosis Antibodies  >1 publications with DBNL and Fibrosis
 Nervous System Diseases Antibodies  >1 publications with DBNL and Nervous System Diseases
 Hypertension Antibodies  >1 publications with DBNL and Hypertension
 Cardiovascular Diseases Antibodies  >1 publications with DBNL and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with DBNL and Disease Models, Animal
 Adenocarcinoma Antibodies  >1 publications with DBNL and Adenocarcinoma
 Necrosis Antibodies  >1 publications with DBNL and Necrosis
 Abnormalities, Multiple Antibodies  >1 publications with DBNL and Abnormalities, Multiple

Organs/Tissues associated with anti-DBNL antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with DBNL and Brain
 Blood Antibodies  >4 publications with DBNL and Blood
 Heart Antibodies  >3 publications with DBNL and Heart
 Lung Antibodies  >3 publications with DBNL and Lung
 Spleen Antibodies  >2 publications with DBNL and Spleen
 Prostate Antibodies  >1 publications with DBNL and Prostate
 Pancreas Antibodies  >1 publications with DBNL and Pancreas
 Thymus Antibodies  >1 publications with DBNL and Thymus
 Embryonic Tissue Antibodies  >1 publications with DBNL and Embryonic Tissue
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