DDX39 Antibody – Rabbit Polyclonal

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

DDX39: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. Belongs to the DEAD box helicase family. DECD subfamily.

Protein type: RNA-binding; EC 3.6.4.13; RNA splicing; Helicase

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; spliceosome

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; ATPase activity; protein binding

Biological Process: mRNA 3'-end processing; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; regulation of gene expression; response to DNA damage stimulus; RNA export from nucleus; RNA secondary structure unwinding; termination of RNA polymerase II transcription