Rabbit Anti-DIS3L Polyclonal Antibody – Cat# MBS768627

K-562 cells were subjected to SDS PAGE followed by western blot with MBS768627 (DIS3L Antibody) at dilution of 1:100

DIS3L Antibody – Rabbit Polyclonal

Name: DIS3L Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS768627
Price: 360 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768627

MBS768627 is an antibody targeting DIS3L. Also known as DIS3L Rabbit Polyclonal. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DIS3L, Polyclonal Antibody

Full Product Name

DIS3L Rabbit Polyclonal

Product Gene Name

anti-DIS3L antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Preparation and Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Molecular Weight

111,119 Da

OMIM

614183

Immunogen

DIS3 mitotic control homolog (S. cerevisiae)-like

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-DIS3L antibody

ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-DIS3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DIS3L. It may not necessarily be applicable to this product.

NCBI GI #

40225951

NCBI GeneID

115752

NCBI Accession #

AAH14124.2

UniProt Secondary Accession #

Q8N1N8; Q8WTU9; Q96CM7

UniProt Related Accession #

Q8TF46

NCBI Official Full Name

DIS3L protein, partial

NCBI Official Synonym Full Names

DIS3 like exosome 3'-5' exoribonuclease

NCBI Official Symbol

DIS3L

NCBI Official Synonym Symbols

DIS3L1

UniProt Protein Name

DIS3-like exonuclease 1

Protein Family

DIS3-like exonuclease

UniProt Gene Name

DIS3L

UniProt Synonym Gene Names

DIS3L1; KIAA1955

UniProt Entry Name

DI3L1_HUMAN

NCBI Protein Information

DIS3-like exonuclease 1

NCBI Summary for DIS3L

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

UniProt Comments for DIS3L

DIS3L: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Belongs to the RNR ribonuclease family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ribonuclease; EC 3.1.13.-

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: centrosome; cytoplasm; nuclear exosome (RNase complex); plasma membrane

Molecular Function: 3'-5'-exoribonuclease activity; enzyme binding; protein binding; RNA binding

Biological Process: mRNA catabolic process; rRNA catabolic process; rRNA processing

Research Articles on DIS3L

1. Data indicate that hDis3L1 is a novel exosome-associated exoribonuclease in the cytoplasm of human cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DIS3L antibody

Products by Pathway	Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram

Diseases associated with anti-DIS3L antibody

Disease Name	Pubmed Publications
Neoplasms, Experimental Antibodies	>1 publications with DIS3L and Neoplasms, Experimental

Organs/Tissues associated with anti-DIS3L antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>1 publications with DIS3L and Skin
Eye Antibodies	>1 publications with DIS3L and Eye
Embryonic Tissue Antibodies	>1 publications with DIS3L and Embryonic Tissue