DNAJA1 Antibody – Rabbit Polyclonal

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

DNAJA1: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.

Protein type: Nuclear receptor co-regulator; Chaperone

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytosol; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; ubiquitin ligase complex

Molecular Function: ATP binding; chaperone binding; G-protein-coupled receptor binding; Hsp70 protein binding; low-density lipoprotein receptor binding; metal ion binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: androgen receptor signaling pathway; DNA damage response, detection of DNA damage; negative regulation of apoptosis; negative regulation of JNK activity; negative regulation of protein ubiquitination; positive regulation of apoptosis; protein folding; regulation of protein transport; response to heat; response to unfolded protein; sperm motility; spermatogenesis