DNAJC10 Antibody – Rabbit Polyclonal

This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

DNAJC10: This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Endoplasmic reticulum; Chaperone

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; membrane

Molecular Function: ATPase activator activity; ATPase binding; chaperone binding; disulfide oxidoreductase activity; Hsp70 protein binding; misfolded protein binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide oxidoreductase activity

Biological Process: cell redox homeostasis; ER-associated protein catabolic process; negative regulation of protein amino acid phosphorylation; positive regulation of ATPase activity