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DNASE2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768710

MBS768710 is an antibody targeting DNASE2B. Also known as DNASE2B Rabbit Polyclonal. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DNASE2B, Polyclonal Antibody
Full Product Name
DNASE2B Rabbit Polyclonal
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
17,816 Da
OMIM
608057
Immunogen
Deoxyribonuclease II beta
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DNASE2B antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-DNASE2B antibody

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using MBS768710 (DNASE2B Antibody) at dilution of 1:50
Rabbit Anti-DNASE2B Polyclonal Antibody – Cat# MBS768710

Western Blot (WB) of anti-DNASE2B antibody

Jurkat cells were subjected to SDS PAGE followed by western blot with MBS768710 (DNASE2B Antibody) at dilution of 1:2000
Rabbit Anti-DNASE2B Polyclonal Antibody, Western Blot (WB) – Cat# MBS768710

Other Notes

Small volumes of anti-DNASE2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DNASE2B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
DNASE2B protein, partial
NCBI Official Synonym Full Names
deoxyribonuclease II beta
NCBI Official Symbol
DNASE2B
NCBI Official Synonym Symbols
DLAD
UniProt Protein Name
Deoxyribonuclease-2-beta
UniProt Synonym Protein Names
DNase II-like acid DNase; DNase2-like acid DNase; Deoxyribonuclease II beta; DNase II beta; Endonuclease DLAD
Protein Family
UniProt Gene Name
DNASE2B
UniProt Synonym Gene Names
DLAD; DNase II beta
UniProt Entry Name
DNS2B_HUMAN
NCBI Protein Information
deoxyribonuclease-2-beta

NCBI Summary for DNASE2B

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for DNASE2B

DNASE2B: Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. Belongs to the DNase II family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.22.1; Deoxyribonuclease

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular region; intracellular; lysosome

Molecular Function: deoxyribonuclease II activity

Biological Process: DNA fragmentation during apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DNASE2B antibody

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