DNM2 Antibody – Rabbit Polyclonal

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

DYN2: a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described.

Protein type: EC 3.6.5.5; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle; Hydrolase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: centrosome; clathrin-coated endocytic vesicle; coated pit; cytoplasm; cytosol; endosome; focal adhesion; Golgi apparatus; Golgi membrane; growth cone; lamellipodium; microtubule; midbody; nucleus; perinuclear region of cytoplasm; phagocytic cup; photoreceptor inner segment; plasma membrane; postsynaptic density; postsynaptic membrane; protein complex; trans-Golgi network

Molecular Function: D2 dopamine receptor binding; enzyme binding; GTP binding; GTPase activity; microtubule binding; nitric-oxide synthase binding; protein binding; protein kinase binding; SH3 domain binding; WW domain binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; G-protein coupled receptor internalization; G2/M transition of mitotic cell cycle; Golgi to plasma membrane transport; negative regulation of transforming growth factor beta receptor signaling pathway; neurite morphogenesis; positive regulation of apoptosis; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of transcription, DNA-dependent; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of nitric-oxide synthase activity; regulation of Rac protein signal transduction; regulation of transcription, DNA-dependent; response to cocaine; response to light stimulus; signal transduction; spermatogenesis; synaptic vesicle transport; transferrin transport

Disease: Charcot-marie-tooth Disease, Dominant Intermediate B; Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1