Rabbit Anti-DOC2B Polyclonal Antibody – Cat# MBS768723

mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS768723 (DOC2B antibody) at dilution of 1:600

DOC2B Antibody – Rabbit Polyclonal

Name: DOC2B Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS768723
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768723

MBS768723 is an antibody targeting DOC2B. Also known as DOC2B Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DOC2B, Polyclonal Antibody

Full Product Name

DOC2B Rabbit Polyclonal

Product Gene Name

anti-DOC2B antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid

Purity/Purification

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Preparation and Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Molecular Weight

45,949 Da

OMIM

604568

Immunogen

Double C2-like domains, beta

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-DOC2B antibody

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Other Notes

Small volumes of anti-DOC2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOC2B. It may not necessarily be applicable to this product.

NCBI GI #

295054132

NCBI GeneID

8447

NCBI Accession #

NP_003576.2

UniProt Related Accession #

Q14184

GenBank Nucleotide #

NM_003585.4

NCBI Official Full Name

double C2-like domain-containing protein beta

NCBI Official Synonym Full Names

double C2 domain beta

NCBI Official Symbol

DOC2B

NCBI Official Synonym Symbols

DOC2BL

UniProt Protein Name

Double C2-like domain-containing protein beta

Protein Family

Double C2-like domain-containing protein

UniProt Gene Name

DOC2B

UniProt Synonym Gene Names

DOC2BL; Doc2-beta

UniProt Entry Name

DOC2B_HUMAN

NCBI Protein Information

double C2-like domain-containing protein beta

NCBI Summary for DOC2B

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

UniProt Comments for DOC2B

DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; plasma membrane; SNARE complex

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; positive regulation of calcium ion-dependent exocytosis; positive regulation of insulin secretion; positive regulation of vesicle fusion; protein localization; regulation of calcium ion-dependent exocytosis; vesicle fusion

Research Articles on DOC2B

1. promoter hypermethylation and silencing of the DOC2B gene is an early and frequent event during cervical carcinogenesis and whose reduced expression due to DNA promoter methylation may lead to selective cervical tumor growth

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DOC2B antibody

Disease Name	Pubmed Publications
Glucose Intolerance Antibodies	>2 publications with DOC2B and Glucose Intolerance
Heart Defects, Congenital Antibodies	>1 publications with DOC2B and Heart Defects, Congenital
Genital Diseases, Female Antibodies	>1 publications with DOC2B and Genital Diseases, Female
Prenatal Exposure Delayed Effects Antibodies	>1 publications with DOC2B and Prenatal Exposure Delayed Effects
Disease Models, Animal Antibodies	>1 publications with DOC2B and Disease Models, Animal