DOK1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function: insulin receptor binding; protein binding; receptor signaling protein activity

Biological Process: cell surface receptor linked signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway