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DOK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768735

MBS768735 is an antibody targeting DOK4. Also known as DOK4 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DOK4, Polyclonal Antibody
Full Product Name
DOK4 Rabbit Polyclonal
Product Gene Name
anti-DOK4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
37,028 Da
OMIM
608333
Immunogen
Docking protein 4
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DOK4 antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-DOK4 antibody

Immunohistochemical of paraffin-embedded human prostate cancer using MBS768735 (DOK4 antibody) at dilution of 1:50
Rabbit Anti-DOK4 Polyclonal Antibody – Cat# MBS768735

Other Notes

Small volumes of anti-DOK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK4. It may not necessarily be applicable to this product.

NCBI GI #
20070302
NCBI GeneID
55715
NCBI Accession #
NP_060580.2
UniProt Secondary Accession #
O75209; Q9BTP2; Q9NVV3
UniProt Related Accession #
Q8TEW6
GenBank Nucleotide #
NM_018110.3
NCBI Official Full Name
docking protein 4
NCBI Official Synonym Full Names
docking protein 4
NCBI Official Symbol
DOK4
NCBI Official Synonym Symbols
IRS5; IRS-5
UniProt Protein Name
Docking protein 4
UniProt Synonym Protein Names
Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5
Protein Family
Docking protein
UniProt Gene Name
DOK4
UniProt Synonym Gene Names
IRS-5; IRS5
UniProt Entry Name
DOK4_HUMAN
NCBI Protein Information
docking protein 4

UniProt Comments for DOK4

DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062.

Protein type: Adaptor/scaffold; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: intracellular

Molecular Function: insulin receptor binding; protein binding; receptor signaling protein activity

Biological Process: MAPKKK cascade; nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway
Show more

Research Articles on DOK4

1. the current study have explored in more detail the structure and function of the Dok-4 PTB domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DOK4 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram

Diseases associated with anti-DOK4 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >3 publications with DOK4 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >3 publications with DOK4 and Adenocarcinoma
 Lung Neoplasms Antibodies  >2 publications with DOK4 and Lung Neoplasms
 Necrosis Antibodies  >2 publications with DOK4 and Necrosis
 Liver Diseases Antibodies  >1 publications with DOK4 and Liver Diseases
 Lymphoma Antibodies  >1 publications with DOK4 and Lymphoma
 Kidney Diseases Antibodies  >1 publications with DOK4 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with DOK4 and Breast Neoplasms
 Poisoning Antibodies  >1 publications with DOK4 and Poisoning
 Inflammation Antibodies  >1 publications with DOK4 and Inflammation

Organs/Tissues associated with anti-DOK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with DOK4 and Muscle
 Lung Antibodies  >3 publications with DOK4 and Lung
 Kidney Antibodies  >3 publications with DOK4 and Kidney
 Liver Antibodies  >2 publications with DOK4 and Liver
 Vascular Antibodies  >2 publications with DOK4 and Vascular
 Connective Tissue Antibodies  >1 publications with DOK4 and Connective Tissue
 Skin Antibodies  >1 publications with DOK4 and Skin
 Embryonic Tissue Antibodies  >1 publications with DOK4 and Embryonic Tissue
 Heart Antibodies  >1 publications with DOK4 and Heart
 Intestine Antibodies  >1 publications with DOK4 and Intestine
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