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DPEP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768745

MBS768745 is an antibody targeting DPEP1. Also known as DPEP1 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DPEP1, Polyclonal Antibody
Full Product Name
DPEP1 Rabbit Polyclonal
Product Gene Name
anti-DPEP1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
45,674 Da
OMIM
179780
Immunogen
Dipeptidase 1 (renal)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-DPEP1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-DPEP1 antibody

Immunohistochemistry of paraffin-embedded human kidney tissue slide using MBS768745 (DPEP1 Antibody) at dilution of 1:200
Rabbit Anti-DPEP1 Polyclonal Antibody – Cat# MBS768745

Western Blot (WB) of anti-DPEP1 antibody

mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS768745 (DPEP1 Antibody) at dilution of 1:300
Rabbit Anti-DPEP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768745

Other Notes

Small volumes of anti-DPEP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPEP1. It may not necessarily be applicable to this product.

NCBI GI #
189458885
NCBI GeneID
1800
NCBI Accession #
NP_001121613.1
UniProt Secondary Accession #
Q96AK2; D3DX80
UniProt Related Accession #
P16444
GenBank Nucleotide #
NM_001128141.2
NCBI Official Full Name
dipeptidase 1
NCBI Official Synonym Full Names
dipeptidase 1 (renal)
NCBI Official Symbol
DPEP1
NCBI Official Synonym Symbols
MDP; RDP; MBD1
UniProt Protein Name
Dipeptidase 1
UniProt Synonym Protein Names
Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP
Protein Family
Dipeptidase
UniProt Gene Name
DPEP1
UniProt Synonym Gene Names
MDP; RDP; hRDP
UniProt Entry Name
DPEP1_HUMAN
NCBI Protein Information
dipeptidase 1

NCBI Summary for DPEP1

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for DPEP1

DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family.

Protein type: Membrane protein, GPI anchor; EC 3.4.13.19; Protease

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: apical part of cell; apical plasma membrane; extracellular space; microvillus membrane; plasma membrane

Molecular Function: caspase inhibitor activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity; protein binding; zinc ion binding

Biological Process: antibiotic metabolic process; glutathione metabolic process; homocysteine metabolic process; leukotriene metabolic process; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell migration; proteolysis; xenobiotic metabolic process
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Research Articles on DPEP1

1. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DPEP1 antibody

 Products by Pathway  Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway antibodies  Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram

Diseases associated with anti-DPEP1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with DPEP1 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with DPEP1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >1 publications with DPEP1 and Nervous System Diseases
 Proteinuria Antibodies  >1 publications with DPEP1 and Proteinuria
 Ovarian Neoplasms Antibodies  >1 publications with DPEP1 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with DPEP1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with DPEP1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with DPEP1 and Kidney Diseases

Organs/Tissues associated with anti-DPEP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with DPEP1 and Kidney
 Intestine Antibodies  >4 publications with DPEP1 and Intestine
 Lymph Node Antibodies  >2 publications with DPEP1 and Lymph Node
 Pancreas Antibodies  >1 publications with DPEP1 and Pancreas
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