EAAT3 Antibody – Rabbit Polyclonal

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; cysteine transmembrane transporter activity; glutamate binding; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; protein binding; sodium:dicarboxylate symporter activity

Biological Process: cysteine transport; glutamate secretion; ion transport; L-glutamate import; positive regulation of heart rate; protein homooligomerization; synaptic transmission

Disease: Schizophrenia 18