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EDC4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS768863

MBS768863 is an antibody targeting EDC4. Also known as EDC4 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EDC4, Polyclonal Antibody
Full Product Name
EDC4 Rabbit Polyclonal
Product Gene Name
anti-EDC4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
109,728 Da
OMIM
606030
Immunogen
Enhancer of mRNA decapping 4
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-EDC4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-EDC4 antibody

Immunohistochemistry of paraffin-embedded human liver cancer using MBS768863 (EDC4 antibody) at dilution of 1:50
Rabbit Anti-EDC4 Polyclonal Antibody – Cat# MBS768863

Western Blot (WB) of anti-EDC4 antibody

HeLa cells were subjected to SDS PAGE followed by western blot with MBS768863 (EDC4 antibody) at dilution of 1:400
Rabbit Anti-EDC4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS768863

Other Notes

Small volumes of anti-EDC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EDC4. It may not necessarily be applicable to this product.

NCBI GI #
45827771
NCBI GeneID
23644
NCBI Accession #
NP_055144.3
UniProt Secondary Accession #
Q13025; Q13826; Q6ZR12; Q7Z6H7; A6NGM1; A8K4T4
UniProt Related Accession #
Q6P2E9
GenBank Nucleotide #
NM_014329.4
NCBI Official Full Name
enhancer of mRNA-decapping protein 4
NCBI Official Synonym Full Names
enhancer of mRNA decapping 4
NCBI Official Symbol
EDC4
NCBI Official Synonym Symbols
GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8
UniProt Protein Name
Enhancer of mRNA-decapping protein 4
UniProt Synonym Protein Names
Autoantigen Ge-1; Autoantigen RCD-8; Human enhancer of decapping large subunit; Hedls
Protein Family
Enhancer of mRNA-decapping protein
UniProt Gene Name
EDC4
UniProt Synonym Gene Names
HEDLS; Hedls
UniProt Entry Name
EDC4_HUMAN
NCBI Protein Information
enhancer of mRNA-decapping protein 4

UniProt Comments for EDC4

EDC4: a protein required for the 5' a?? 3' pathway of mRNA decapping and degradation-based post-transcriptional gene silencing. The proteins involved in 5' a?? 3' mRNA decay include DCP2, DCP1A, EDC3, EDC4 and DDX6, and are concentrated in cytoplasmic structures called mRNA "processing bodies" (P-bodies). Shortening of the 3'-poly(A) tail and removal of PABP precedes cleavage of the 5'-mRNA cap by a complex containing decapping enzymes 1A and 2 (DCP1A/DCP2). EDC4 enhances the catalytic activity of DCP2 in vitro. Shown to be required for silencing by miRNAs in Drosophila melanogaster. Two alternatively spliced human isoforms have been described.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nucleoplasm; nucleus

Molecular Function: protein binding
Show more

Research Articles on EDC4

1. The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EDC4 antibody

 Reference Product  PubMed Publications
 DCP2 antibody  >17 publications with EDC4 and DCP2
 XRN1 antibody  >9 publications with EDC4 and XRN1
 EDC3 antibody  >7 publications with EDC4 and EDC3
 LSM1 antibody  >6 publications with EDC4 and LSM1
 EIF2C2 antibody  >2 publications with EDC4 and EIF2C2
 PATL1 antibody  >2 publications with EDC4 and PATL1
 LSM4 antibody  >1 publications with EDC4 and LSM4

Pathways associated with anti-EDC4 antibody

 Products by Pathway  Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 MRNA Decay By 5' To 3' Exoribonuclease Pathway antibodies  MRNA Decay By 5' To 3' Exoribonuclease Pathway Diagram

Diseases associated with anti-EDC4 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4 publications with EDC4 and Liver Diseases
 Cardiovascular Diseases Antibodies  >2 publications with EDC4 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with EDC4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with EDC4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with EDC4 and Liver Neoplasms
 Necrosis Antibodies  >1 publications with EDC4 and Necrosis

Organs/Tissues associated with anti-EDC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with EDC4 and Blood
 Liver Antibodies  >4 publications with EDC4 and Liver
 Muscle Antibodies  >3 publications with EDC4 and Muscle
 Nerve Antibodies  >2 publications with EDC4 and Nerve
 Kidney Antibodies  >1 publications with EDC4 and Kidney
 Lung Antibodies  >1 publications with EDC4 and Lung
 Skin Antibodies  >1 publications with EDC4 and Skin
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