EDF1 Antibody – Rabbit Polyclonal

This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

EDF1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; RNA-binding; DNA-binding

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; intracellular; nucleolus; nucleus; transcription factor TFIID complex

Molecular Function: calmodulin binding; histone acetyltransferase activity; methyltransferase activity; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity

Biological Process: endothelial cell differentiation; multicellular organismal development; positive regulation of DNA binding; positive regulation of transcription, DNA-dependent; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent