EPHA4 Antibody – Rabbit Polyclonal

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Eph family

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: axon; cell junction; cell surface; cytoplasm; dendrite; dendritic spine; early endosome membrane; endoplasmic reticulum; filopodium; Golgi apparatus; integral to plasma membrane; mitochondrial outer membrane; nerve terminal; neuromuscular junction; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: ATP binding; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; PH domain binding; protein binding; protein kinase activity; transmembrane-ephrin receptor activity

Biological Process: adult walking behavior; cell adhesion; corticospinal tract morphogenesis; ephrin receptor signaling pathway; glial cell migration; motor axon guidance; negative regulation of axon regeneration; peptidyl-tyrosine phosphorylation; positive regulation of dendrite morphogenesis; positive regulation of JNK activity; protein amino acid autophosphorylation; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of GTPase activity