Ephrin B1 (EFNB1) Antibody – Rabbit Polyclonal

EFNB1: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: cytoplasm; integral to plasma membrane; lipid raft; nucleus; plasma membrane; synapse

Molecular Function: ephrin receptor binding; protein binding

Biological Process: axon guidance; cell adhesion; cell-cell signaling; embryonic pattern specification; ephrin receptor signaling pathway; neural crest cell migration; positive regulation of T cell proliferation; T cell costimulation

Disease: Craniofrontonasal Syndrome